Salicylic acid: an old dog, new tricks, and staphylococcal disease.

نویسنده

  • Mathias Herrmann
چکیده

Aspirin has been shown to cause a reduction in the virulence of Staphylococcus aureus-associated endocarditis. A new study reveals that salicylic acid, the major metabolite of aspirin, acts at the level of transcription to downregulate the production of fibrinogen, fibronectin, and alpha-hemolysin - virulence factors necessary for bacterial replication in host tissues and, now, potential therapeutic targets.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The ECG in acute coronary syndromes: new tricks from an old dog.

The ECG remains the pre-eminent test for myocardial ischaemia, directing therapeutic management and prognostic stratification.

متن کامل

The effect of salicylic acid and jasmonic acid on the symptoms of the disease and the expression of defense genes on a greenhouse cucumber infected with CMV

Cucumber is one of the most important vegetable and summer crops economically and is the fourth most cultivated plant in the world after tomatoes and potatoes. In this study, the effect of plant inducers including salicylic acid and jasmonic acid on the viral disease of greenhouse cucumber with Cucumber mosaic virus (CMV) and also the expression of defense genes was investigated. Treatments inc...

متن کامل

GCN2, an old dog with new tricks.

Gcn2 was first described in budding yeast as a serine/threonine protein kinase involved in the response to amino acid starvation and this is its best characterized role to date. Recent work has revealed new and exciting roles for Gcn2, which affect many aspects of cellular physiology in response to a number of stresses in addition to starvation. Furthermore, the Gcn2 pathway has been implicated...

متن کامل

Can old dogs learn new tricks?

Many of these old adages can’t be traced back to their origins, but the reference to senior dogs and their learning capacity has a documented origin. The source of these well-worn words is an English gentleman named Fitzherbert who wrote a treatise on animal husbandry in 1523. In the cumbersome vernacular of the times, he said that “the dogge must lerne when he is a whelpe, or els it wyl not be...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • The Journal of clinical investigation

دوره 112 2  شماره 

صفحات  -

تاریخ انتشار 2003